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Philos Trans R Soc Lond B Biol Sci. 2009 Mar 12;364(1517):631-7. doi: 10.1098/rstb.2008.0209.

Shhh! Silencing by microRNA-155.

Author information

  • 1Laboratory of Lymphocyte Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Abstract

Small RNAs mediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from 'classical' RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and oncogenesis.

PMID:
19008191
[PubMed - indexed for MEDLINE]
PMCID:
PMC2660923
Free PMC Article
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