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Infect Immun. 1991 Apr;59(4):1558-63.

T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis.

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  • 1Vaccine Department, Statens Seruminstitut, Copenhagen, Denmark.


An infection model of human tuberculosis was established with C57BL/6J mice. The lymphocyte proliferative responses to antigens from Mycobacterium tuberculosis were investigated during the course of infection and compared with results obtained with a group of mice immunized with large amounts of killed bacteria. The two groups responded similarly to a number of mycobacterial antigens, but marked differences in responses against secreted antigens were found; only infected mice responded vigorously to these. The responding lymphocyte subpopulation was made up of L3T4+ T lymphocytes under restriction of the Ia molecule.

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