Curr Opin Genet Dev. 2008 Dec;18(6):571-82. Epub 2008 Nov 27.

Eukaryotic gene regulation in three dimensions and its impact on genome evolution.

Babu MM, Janga SC, de Santiago I, Pombo A.

Source

MRC Laboratory of Molecular Biology, Cambridge, UK. madanm@mrc-lmb.cam.ac.uk

Abstract

Recent advances in molecular techniques and high-resolution imaging are beginning to provide exciting insights into the higher order chromatin organization within the cell nucleus and its influence on eukaryotic gene regulation. This improved understanding of gene regulation also raises fundamental questions about how spatial features might have constrained the organization of genes on eukaryotic chromosomes and how mutations that affect these processes might contribute to disease conditions. In this review, we discuss recent studies that highlight the role of spatial components in gene regulation and their impact on genome evolution. We then address implications for human diseases and outline new directions for future research.

PMID:: 19007886; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

MeSH Terms

Grant Support

Medical Research Council/United Kingdom

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