Immunity. 2008 Nov 14;29(5):670-1. doi: 10.1016/j.immuni.2008.10.005.

"Dangerous crystals".

Source

Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA. anthony.defranco@ucsf.edu

Abstract

Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol.

Comment on

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. [Immunity. 2008]
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, et al. Immunity. 2008 Nov 14; 29(5):807-18.

PMID:: 19006690; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

CHOLESTEROL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. [Immunity. 2008]
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells.
Ng G, Sharma K, Ward SM, Desrosiers MD, Stephens LA, Schoel WM, Li T, Lowell CA, Ling CC, Amrein MW, et al. Immunity. 2008 Nov 14; 29(5):807-18.
Review Immune activation: death, danger and dendritic cells. [Curr Biol. 2004]
Review Immune activation: death, danger and dendritic cells.
Pulendran B. Curr Biol. 2004 Jan 6; 14(1):R30-2.
Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C. [J Immunol. 2009]
Crystal-induced neutrophil activation: XI. Implication and novel roles of classical protein kinase C.
Popa-Nita O, Proulx S, Paré G, Rollet-Labelle E, Naccache PH. J Immunol. 2009 Aug 1; 183(3):2104-14. Epub 2009 Jul 13.
Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses. [Blood. 2008]
Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses.
Leibundgut-Landmann S, Osorio F, Brown GD, Reis e Sousa C. Blood. 2008 Dec 15; 112(13):4971-80. Epub 2008 Sep 25.
Review Syk and pTyr'd: Signaling through the B cell antigen receptor. [Biochim Biophys Acta. 2009]
Review Syk and pTyr'd: Signaling through the B cell antigen receptor.
Geahlen RL. Biochim Biophys Acta. 2009 Jul; 1793(7):1115-27. Epub 2009 Mar 21.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

"Dangerous crystals".
"Dangerous crystals".
Immunity. 2008 Nov 14 ;29(5):670-1. doi: 10.1016/j.immuni.2008.10.005.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

"Dangerous crystals".

Source

Abstract

Comment on

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information