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Immunity. 2008 Nov 14;29(5):670-1. doi: 10.1016/j.immuni.2008.10.005.

"Dangerous crystals".

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  • 1Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA.


Uric acid (UA) crystals are a potent stimulator of inflammation, but how they activate immune cells is not known. In this issue of Immunity, Ng et al. (2008) provide evidence suggesting that UA activates the Syk kinase via membrane cholesterol.

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