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J Lipid Res. 2009 Apr;50 Suppl:S249-54. doi: 10.1194/jlr.R800072-JLR200. Epub 2008 Nov 11.

Phosphoinositide phosphatases and disease.

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  • 1Division of Hematology, Washington University School of Medicine, Box 8125, St. Louis, MO 63110, USA.


The field of inositol signaling has expanded greatly in recent years. Given the many reviews on phosphoinositide kinases, we have chosen to restrict our discussion to inositol lipid hydrolysis focused on the phosphatases and a brief mention of the lipase isoforms. We also discuss recent discoveries that link mutations in phosphoinositide phosphatases to disease.

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