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Arch Neurol. 2008 Nov;65(11):1460-4. doi: 10.1001/archneur.65.11.1460.

Treatment of chronic inflammatory demyelinating polyneuropathy with pulsed oral steroids.

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  • 1Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA. muley001@umn.edu

Abstract

BACKGROUND:

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy that responds to various immunosuppressive treatments. Oral daily prednisone therapy is effective and inexpensive, but the long-term treatment that is usually necessary leads to serious adverse effects. Consequently, intravenous immunoglobulin and plasma exchange have been widely used to treat CIDP, making treatment expensive and inconvenient. A steroid regimen that reduces adverse effects but preserves efficacy would simplify treatment. Pulsed steroids have nongenomic actions not seen with low-dose steroids, including rapid inhibition of arachidonic acid release and of calcium and sodium cycling across plasma membranes of immune cells.

OBJECTIVE:

To study the efficacy, safety, and tolerability of pulsed oral methylprednisolone therapy in patients with CIDP.

DESIGN:

Open-label prospective study.

SETTING:

University of Minnesota Neuropathy Center, Minneapolis.

PATIENTS:

Ten patients (3 women and 7 men) with CIDP followed up for at least 22 months.

MAIN OUTCOME MEASURES:

Neuromuscular score and Inflammatory Neuropathy Cause and Treatment (INCAT) disability score were used as outcome measures for efficacy; weight, blood pressure, changes in bone density, and steroid-related adverse effect questionnaire were used as outcome measures for safety.

RESULTS:

This steroid regimen leads to significant improvement in weakness and disability in all patients treated and to off-treatment remission in 60% of patients. Treatment was fairly well tolerated, and only 1 patient discontinued treatment because of adverse effects. Steroid-induced osteoporosis remained a problem, especially in older patients.

CONCLUSIONS:

Pulsed oral methylprednisolone may be efficacious in the long-term treatment of CIDP and is relatively well tolerated. Remission can be induced in most patients, especially those with a shorter duration of disease.

PMID:
19001164
[PubMed - indexed for MEDLINE]
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