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Int Urol Nephrol. 2009;41(3):553-7. doi: 10.1007/s11255-008-9495-8. Epub 2008 Nov 8.

A distinctive translocation carcinoma of the kidney ["rosette-like forming," t(6;11), HMB45-positive renal tumor].

Author information

  • 1Department of Urology, Charles University Hospital, Plzen, Czech Republic. horam@fnplzen.cz

Abstract

OBJECTIVE:

Recently, a novel renal carcinoma with specific clinical and histological characteristics and translocation t(6;11)(p21.1;q12 or q13) has been identified. We have found 11 cases in the literature, and we are adding another 3 cases.

MATERIALS AND METHODS:

Three cases were found in the Plzen pathological register with approximately 15,000 cases of kidney tumors. There were two females and 1 male, aged 22, 24, and 39 years.

RESULTS:

The sizes of the tumors were 40, 136, and 10 mm. Two tumors were found incidentally; the biggest one was self-palpated by a 24-year-old pregnant patient. Patients are without any signs of disease 42, 20, and 17 months after surgery.

CONCLUSION:

This tumor is a distinctive and rare translocation carcinoma of the kidney [t(6;11), HMB45 positive]. All cases with known clinical data arose in younger people. The malignant potential is probably low.

PMID:
18998233
[PubMed - indexed for MEDLINE]
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