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J Invest Dermatol. 2008 Dec;128(12):2750-2. doi: 10.1038/jid.2008.341.

Tumor evasion may occur via expression of regulatory molecules: a case for CTLA-4 in melanoma.

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  • H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA. jeffrey.weber@moffitt.org


Emerging data that show immune-regulating molecules may be ectopically expressed on human tumors suggest that novel mechanisms may induce tumor-related immune suppression, and support the use of antibodies and small molecules to target those immune-suppressive moities.

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