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Clin Chim Acta. 2009 Feb;400(1-2):97-102. doi: 10.1016/j.cca.2008.10.021. Epub 2008 Oct 30.

Detection of miR-106a in gastric carcinoma and its clinical significance.

Author information

  • 1Ningbo University, School of Medicine, Ningbo 315211, China. xiaobingxiu@nbu.edu.cn

Abstract

BACKGROUND:

MicroRNAs (miRNAs) play important roles in carcinogenesis. miRNA-106a (miR-106a) has oncogenic activity in humans, and often has altered expression. The clinical significance of miR-106a in the diagnosis of gastric carcinoma is poorly understood.

METHODS:

The level of miR-106a in 55 gastric carcinoma and 17 non-tumor tissues was quantified by real-time reverse transcriptase-polymerase chain reaction, and the relationship between miR-106a level and clinical and pathological factors was explored.

RESULTS:

The level of miR-106a in cancer tissues was significantly higher than that in non-tumor tissues, with an average 1.625-fold increase. miR-106a level was significantly associated with tumor stage, size and differentiation; lymphatic and distant metastasis; and invasion (P<0.01). The altered expression of miR-106a was confirmed in gastric cancer cell lines.

CONCLUSION:

miR-106a may be a potential biomarker in the diagnosis of gastric carcinoma.

PMID:
18996365
[PubMed - indexed for MEDLINE]
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