A variant translocation t(2;18) in follicular lymphoma involves the 5' end of bcl-2 and Ig kappa light chain gene

Oncogene. 1991 Jan;6(1):169-72.

Abstract

We have examined three cases of human lymphoma bearing a t(2;18)(p11;q21) chromosome translocation. The bcl-2 gene appeared to be rearranged in all three cases and breakpoints were clustered in the 5' flanking region of the gene. In all three cases, bcl-2 was juxtaposed to J segments of the Ig kappa gene. This juxtaposition of the bcl-2 and Ig kappa genes is very similar to the variant chromosome translocations of Burkitt lymphoma that juxtapose the c-myc locus to IgL genes.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blotting, Southern
  • Chromosomes, Human, Pair 18*
  • Chromosomes, Human, Pair 2*
  • DNA Probes
  • Female
  • Humans
  • Immunoglobulin kappa-Chains / genetics*
  • Lymphoma, Follicular / genetics*
  • Male
  • Middle Aged
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-bcl-2
  • Translocation, Genetic*

Substances

  • DNA Probes
  • Immunoglobulin kappa-Chains
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2