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    Science. 1991 Feb 1;251(4993):561-5.

    Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily.

    Ladias JA, Karathanasis SK.

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    Department of Cardiology, Children's Hospital, Boston, MA.

    Abstract

    Apolipoprotein AI (apoAI) is a lipid-binding protein that participates in the transport of cholesterol and other lipids in the plasma. A complementary DNA clone for a protein that bound to regulatory elements of the apoAI gene was isolated. This protein, designated apoAI regulatory protein-1 (ARP-1), is a novel member of the steroid hormone receptor superfamily. ARP-1 bound to DNA as a dimer, and its dimerization domain was localized to the COOH-terminal region. ARP-1 also bound to a thyroid hormone-responsive element and to regulatory regions of the apoB, apoCIII, insulin, and ovalbumin genes. In cotransfection experiments, ARP-1 downregulated the apoAI gene. The involvement of ARP-1 in the regulation of apoAI gene expression suggests that it may participate in lipid metabolism and cholesterol homeostasis.

    PMID:
    1899293
    [PubMed - indexed for MEDLINE]

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