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Cancer Genet Cytogenet. 2008 Nov;187(1):39-42. doi: 10.1016/j.cancergencyto.2008.07.007.

Embryonal rhabdomyosarcoma with a novel t(2;6)(p23;p21.1).

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  • 1Department of Pediatrics, Division of Hematology-Oncology, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 512, Birmingham, AL 35233, USA.


Chromosomal translocations are infrequently encountered in embryonal rhabdomyosarcoma (E-RMS). Here, we present a case of an infant with a chest wall E-RMS in which t(2;6)(p23;p21.1) was detected. Despite the involvement of the 2p23 locus in the translocation, the tumor did not express ALK. The t(2;6)(p23;p21.1) is a novel finding in E-RMS that may provide insight into the pathogenesis of this relatively frequent childhood tumor.

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