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Genomics. 2009 Feb;93(2):105-11. doi: 10.1016/j.ygeno.2008.10.003. Epub 2008 Nov 21.

Generations of sequencing technologies.

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  • 1Department of Gene Technology, Royal Institute of Technology (KTH), AlbaNova University Center, Roslagstullsbacken 21, SE-10691 Stockholm, Sweden. eriq@kth.se

Abstract

Advancements in the field of DNA sequencing are changing the scientific horizon and promising an era of personalized medicine for elevated human health. Although platforms are improving at the rate of Moore's Law, thereby reducing the sequencing costs by a factor of two or three each year, we find ourselves at a point in history where individual genomes are starting to appear but where the cost is still too high for routine sequencing of whole genomes. These needs will be met by miniaturized and parallelized platforms that allow a lower sample and template consumption thereby increasing speed and reducing costs. Current massively parallel, state-of-the-art systems are providing significantly improved throughput over Sanger systems and future single-molecule approaches will continue the exponential improvements in the field.

PMID:
18992322
[PubMed - indexed for MEDLINE]
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