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Schizophr Bull. 2009 Mar;35(2):362-9. doi: 10.1093/schbul/sbn143. Epub 2008 Nov 5.

Clinical recovery in first-episode psychosis.

Author information

  • 1University Medical Center Groningen, University Psychiatric Center (5.21), University of Groningen, 9700 RB Groningen, The Netherlands. a.wunderink@med.umcg.nl

Abstract

INTRODUCTION:

Generally agreed outcome criteria in psychosis are required to evaluate the effectiveness of new treatment strategies. The aim of this study is to explore clinical recovery in first-episode patients, defined by meeting criteria for both symptomatic and functional remission.

METHOD:

In a sample of first-episode patients (N = 125), symptomatic and functional remission during the last 9 months of a 2-year follow-up period were examined, as well as recovery and its predictors.

RESULTS:

Half the patients (52.0%) showed symptomatic remission and a quarter (26.4%) functional remission, while one-fifth (19.2%) met both criteria sets and were considered recovered. Recovery was significantly associated with short duration of untreated psychosis and better baseline functioning.

CONCLUSION:

Most functionally remitted patients were also symptomatically remitted, while a minority of symptomatically remitted patients were also functionally remitted. Treatment delay may affect chance of recovery.

PMID:
18990715
[PubMed - indexed for MEDLINE]
PMCID:
PMC2659307
Free PMC Article
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