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    Expert Opin Biol Ther. 2008 Dec;8(12):1867-72.

    The role of NLRs and TLRs in the activation of the inflammasome.

    Netea MG, van de Veerdonk FL, Kullberg BJ, Van der Meer JW, Joosten LA.

    Source

    Radboud University Nijmegen Medical Center, Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Department of Medicine, Geert Grooteplein 8, 6525 GA Nijmegen, Netherlands.

    Abstract

    BACKGROUND:

    Interleukin-1 beta is one of the most important pro-inflammatory cytokines. In contrast to other cytokines, activation of IL-1 beta requires processing from an inactive precursor by the cysteine protease caspase-1. Caspase-1 forms a protein platform called the inflammasome, together with proteins of the nucleotide-binding oligomerization domain-like receptor (NLR) family.

    OBJECTIVE/METHODS:

    A review of literature investigating the stimulation of IL-1 beta production by microbial pathogens and their components.

    RESULTS/CONCLUSIONS:

    To produce IL-1 beta, macrophages need a double stimulation with Toll like receptor (TLR) ligands that induce gene transcription, and NLR agonists (such as ATP or muramyl dipeptide (MDP)) that activate the inflammasome. Monocytes can release active IL-1 beta upon stimulation with TLR ligands alone. This probably represents an adaptation of each cell type to its environment.

    PMID:
    18990074
    [PubMed - indexed for MEDLINE]

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