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Autophagy. 2009 Jan;5(1):93-5.

Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form.

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  • 1Division of Pharmacology, Faculty of Health Sciences, Link√∂ping University, Link√∂ping, Sweden.

Abstract

Lysosomes contain most of the cell's supply of labile iron, which makes them sensitive to oxidative stress. To keep lysosomal labile iron at a minimum, a cellular strategy might be to autophagocytose iron binding proteins that temporarily would chelate iron in a non-redox-active form. Previously we have shown that autophagy of metallothioneins, as well as of non-Fe-saturated ferritin, meets this goal. Here we add another stress-regulated protein to the list, namely HSP70.

PMID:
18989099
[PubMed - indexed for MEDLINE]
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