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    J Inherit Metab Dis. 2008 Dec;31(6):703-17. Epub 2008 Nov 8.

    The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: a review.

    Source

    Metabolic Unit, Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. M.Wamelink@vumc.nl

    Abstract

    The recent discovery of two defects (ribose-5-phosphate isomerase deficiency and transaldolase deficiency) in the reversible part of the pentose phosphate pathway (PPP) has stimulated interest in this pathway. In this review we describe the functions of the PPP, its relation to other pathways of carbohydrate metabolism and an overview of the metabolic defects in the reversible part of the PPP.

    PMID:
    18987987
    [PubMed - indexed for MEDLINE]

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