Exp Cell Res. 1991 Jan;192(1):93-101.

Disruption of the cytoskeleton with cytochalasin D induces c-fos gene expression.

Zambetti G, Ramsey-Ewing A, Bortell R, Stein G, Stein J.

Source

Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655.

Abstract

The treatment of exponentially growing HeLa cells and quiescent WI-38 cells with cytochalasin D, which disrupts the cytoskeletal microfilaments, results in a rapid and marked increase in the transcription of the c-fos protooncogene with a concomitant increase in c-fos mRNA steady-state levels. Transcription of rRNA, HLA-B7, and H4 histone genes was not significantly affected by the drug treatment. These results suggest that the nucleus can respond to signals related to the structural organization of the cytoskeleton and selectively adjust the regulation of gene expression.

PMID:: 1898594; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Early stimulation by EGF plus insulin of rRNA, c-fos, and actin mRNA expression: inhibition by cytochalasin D. [Exp Cell Res. 1987]
Early stimulation by EGF plus insulin of rRNA, c-fos, and actin mRNA expression: inhibition by cytochalasin D.
Rebillard M, Leibovitch S, Jullien M, Talha S, Harel L. Exp Cell Res. 1987 Oct; 172(2):432-8.
Differential association of membrane-bound and non-membrane-bound polysomes with the cytoskeleton. [Exp Cell Res. 1990]
Differential association of membrane-bound and non-membrane-bound polysomes with the cytoskeleton.
Zambetti G, Wilming L, Fey EG, Penman S, Stein J, Stein G. Exp Cell Res. 1990 Dec; 191(2):246-55.
Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts. [J Cell Physiol. 1997]
Cytoskeleton regulates expression of genes for transforming growth factor-beta 1 and extracellular matrix proteins in dermal fibroblasts.
Varedi M, Ghahary A, Scott PG, Tredget EE. J Cell Physiol. 1997 Aug; 172(2):192-9.
Review Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors. [In Vitro Cell Dev Biol. 1988]
Review Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors.
Rollins BJ, Stiles CD. In Vitro Cell Dev Biol. 1988 Feb; 24(2):81-4.
Review Association of mRNA with the cytoskeletal framework: its role in the regulation of gene expression. [Crit Rev Eukaryot Gene Expr. 1...]
Review Association of mRNA with the cytoskeletal framework: its role in the regulation of gene expression.
Pachter JS. Crit Rev Eukaryot Gene Expr. 1992; 2(1):1-18.

See reviews... See all...

Cited by 8 PubMed Central articles

Regulation of Wnt5a expression in human mammary cells by protein kinase C activity and the cytoskeleton. [Br J Cancer. 1998]
Regulation of Wnt5a expression in human mammary cells by protein kinase C activity and the cytoskeleton.
Jönsson M, Smith K, Harris AL. Br J Cancer. 1998 Aug; 78(4):430-8.
Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices. [Mol Cell Biol. 1998]
Increased c-fos mRNA expression by human fibroblasts contracting stressed collagen matrices.
Rosenfeldt H, Lee DJ, Grinnell F. Mol Cell Biol. 1998 May; 18(5):2659-67.
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA. [Mol Cell Biol. 1993]
Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.
Cheng J, Maquat LE. Mol Cell Biol. 1993 Mar; 13(3):1892-902.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Disruption of the cytoskeleton with cytochalasin D induces c-fos gene expression...
Disruption of the cytoskeleton with cytochalasin D induces c-fos gene expression.
Exp Cell Res. 1991 Jan ;192(1):93-101.

PubMed
[Acute tonsillitis].
[Acute tonsillitis].
MMW Fortschr Med. 2008 Oct 16 ;150(42):44-5.

PubMed
Computerised CBT: a review.
Computerised CBT: a review.
Ment Health Today. 2008 Oct :30-1.

PubMed
Gene expression profiling in Daphnia magna, part II: validation of a copper spec...
Gene expression profiling in Daphnia magna, part II: validation of a copper specific gene expression signature with effluent from two copper mines in California.
Environ Sci Technol. 2008 Aug 15 ;42(16):6257-63.

PubMed
[Effects of electroacupuncture combined with psychologic interference on anxiety...
[Effects of electroacupuncture combined with psychologic interference on anxiety state and serum NE content in the patient of internet addiction disorder].
Zhongguo Zhen Jiu. 2008 Aug ;28(8):561-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Disruption of the cytoskeleton with cytochalasin D induces c-fos gene expression.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information