Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Exp Mol Med. 2008 Oct 31;40(5):550-7.

Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis.

Author information

  • 1Department of Anatomy, School of Medicine, Kyungpook National University, Daegu 700-412, Korea.

Abstract

We have previously shown that the inhibition of fibroblast growth factor (FGF) signaling induced endodermal gene expression in the animal cap and caused the expansion of the endodermal mass in Xenopus embryos. However, we still do not know whether or not the alteration of FGF signaling controls embryonic cell fate, or when FGF signal blocking is required for endoderm formation in Xenopus. Here, we show that FGF signal blocking in embryonic cells causes their descendants to move into the endodermal region and to express endodermal genes. It is also interesting that blocking FGF signaling between fertilization and embryonic stage 10.5 promotes endoderm formation, but persistent FGF signaling blocking after stage 10.5 restricts endoderm formation and differentiation.

PMID:
18985013
[PubMed - indexed for MEDLINE]
PMCID:
PMC2679358
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk