The global impact of hepatic fibrosis and end-stage liver disease

Clin Liver Dis. 2008 Nov;12(4):733-46, vii. doi: 10.1016/j.cld.2008.07.007.

Abstract

Hepatic fibrosis is an integral part in the progression of chronic liver disease, ultimately leading to cirrhosis and hepatocellular carcinoma. Globally, alcohol consumption, hepatitis B (HBV) and hepatitis C (HCV) have been the main causes of cirrhosis. More recently, the increasing prevalence of obesity and the metabolic syndrome has resulted in increasing incidence of cirrhosis secondary to nonalcoholic fatty liver disease (NAFLD), especially in developed countries. Chronic liver disease and cirrhosis are important causes of morbidity and mortality in the world. Moreover, the burden of chronic liver disease is projected to increase, due in part to the increasing prevalence of end-stage liver disease and HCC secondary to NAFLD and HCV.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Carcinoma, Hepatocellular / etiology
  • Carcinoma, Hepatocellular / mortality
  • Chronic Disease
  • Global Health*
  • Humans
  • Incidence
  • Liver Cirrhosis / economics
  • Liver Cirrhosis / etiology*
  • Liver Cirrhosis / mortality*
  • Liver Diseases / complications*
  • Liver Diseases / epidemiology*
  • Liver Neoplasms / etiology
  • Liver Neoplasms / mortality
  • Prevalence