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Cell. 2008 Oct 31;135(3):422-35. doi: 10.1016/j.cell.2008.10.008.

The self-tuning neuron: synaptic scaling of excitatory synapses.

Author information

  • Department of Biology, Volen Center for Complex Systems, and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, USA. turrigiano@brandeis.edu

Abstract

Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Additional mechanisms may allow local or network-wide changes in activity to be sensed through parallel pathways, generating a nested set of homeostatic mechanisms that operate over different temporal and spatial scales.

PMID:
18984155
[PubMed - indexed for MEDLINE]
PMCID:
PMC2834419
Free PMC Article

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