Mol Cell Endocrinol. 2009 Mar 5;300(1-2):137-46. Epub 2008 Oct 15.

Shaping the stress response: interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity.

Source

Diabetes Center, University of California San Francisco, 513 Parnassus Avenue, Box 0534, San Francisco, CA 94143-0534, USA. james.warne@ucsf.edu

Abstract

Activity of the hypothalamo-pituitary-adrenal (HPA) axis is regulated by a negative feedback loop that dampens central drive of the axis via the actions of the secreted glucocorticoids. Conversely, under conditions of chronic stress, glucocorticoids delivered centrally increase hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing factor (CRF) expression and the response to restraint. However, HPA axis activity and PVN CRF mRNA expression under chronic stress conditions are often reduced, implying other indirect peripheral or extra-hypothalamic glucocorticoid actions. Glucocorticoids chronically increase palatable food intake, which increases abdominal fat depots and circulating insulin levels, both of which negatively correlate with PVN CRF mRNA expression and may in turn dampen the response to stress. Such an effect is dependent on food choices, rather than total calories ingested. Considering stress is omnipresent in the workplace, palatable food ingestion may represent a means to combat the feeling of stress which is ultimately maladaptive when unresolved.

PMID:: 18984030; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Review The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a site proximal to CRF neurons. [Ann N Y Acad Sci. 1995]
Review The neural network that regulates energy balance is responsive to glucocorticoids and insulin and also regulates HPA axis responsivity at a site proximal to CRF neurons.
Dallman MF, Akana SF, Strack AM, Hanson ES, Sebastian RJ. Ann N Y Acad Sci. 1995 Dec 29; 771:730-42.
Review Feast and famine: critical role of glucocorticoids with insulin in daily energy flow. [Front Neuroendocrinol. 1993]
Review Feast and famine: critical role of glucocorticoids with insulin in daily energy flow.
Dallman MF, Strack AM, Akana SF, Bradbury MJ, Hanson ES, Scribner KA, Smith M. Front Neuroendocrinol. 1993 Oct; 14(4):303-47.
Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress. [Endocrinology. 2004]
Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress.
Pecoraro N, Reyes F, Gomez F, Bhargava A, Dallman MF. Endocrinology. 2004 Aug; 145(8):3754-62. Epub 2004 May 13.
Chronic stress and obesity: a new view of "comfort food". [Proc Natl Acad Sci U S A. 2003]
Chronic stress and obesity: a new view of "comfort food".
Dallman MF, Pecoraro N, Akana SF, La Fleur SE, Gomez F, Houshyar H, Bell ME, Bhatnagar S, Laugero KD, Manalo S. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11696-701. Epub 2003 Sep 15.
The nociceptin/orphanin FQ antagonist UFP-101 differentially modulates the glucocorticoid response to restraint stress in rats during the peak and nadir phases of the hypothalamo-pituitary-adrenal axis circadian rhythm. [Neuroscience. 2007]
The nociceptin/orphanin FQ antagonist UFP-101 differentially modulates the glucocorticoid response to restraint stress in rats during the peak and nadir phases of the hypothalamo-pituitary-adrenal axis circadian rhythm.
Leggett JD, Jessop DS, Fulford AJ. Neuroscience. 2007 Jul 13; 147(3):757-64. Epub 2007 Jun 15.

See reviews... See all...

Cited by 3 PubMed Central articles

Attachment security and obesity in US preschool-aged children. [Arch Pediatr Adolesc Med. 2011]
Attachment security and obesity in US preschool-aged children.
Anderson SE, Whitaker RC. Arch Pediatr Adolesc Med. 2011 Mar; 165(3):235-42.
Increased ghrelin sensitivity and calorie consumption in subordinate monkeys is affected by short-term astressin B administration. [Endocrine. 2010]
Increased ghrelin sensitivity and calorie consumption in subordinate monkeys is affected by short-term astressin B administration.
Michopoulos V, Loucks T, Berga SL, Rivier J, Wilson ME. Endocrine. 2010 Oct; 38(2):227-34. Epub 2010 Jul 17.
Diet choice, cortisol reactivity, and emotional feeding in socially housed rhesus monkeys. [Physiol Behav. 2010]
Diet choice, cortisol reactivity, and emotional feeding in socially housed rhesus monkeys.
Arce M, Michopoulos V, Shepard KN, Ha QC, Wilson ME. Physiol Behav. 2010 Nov 2; 101(4):446-55. Epub 2010 Jul 27.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Shaping the stress response: interplay of palatable food choices, glucocorticoid...
Shaping the stress response: interplay of palatable food choices, glucocorticoids, insulin and abdominal obesity.
Mol Cell Endocrinol. 2009 Mar 5 ;300(1-2):137-46. Epub 2008 Oct 15 .

PubMed
Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogra...
Periodic activation of Wnt/beta-catenin signaling enhances somatic cell reprogramming mediated by cell fusion.
Cell Stem Cell. 2008 Nov 6 ;3(5):493-507.

PubMed
Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in...
Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism.
Free Radic Biol Med. 2009 Jan 15 ;46(2):232-7. Epub 2008 Oct 18 .

PubMed
Audio-visual stimulation improves oculomotor patterns in patients with hemianopi...
Audio-visual stimulation improves oculomotor patterns in patients with hemianopia.
Neuropsychologia. 2009 Jan ;47(2):546-55. Epub 2008 Oct 15 .

PubMed
Effects of trimetazidine on crush injury of the sciatic nerve in rats: a biochem...
Effects of trimetazidine on crush injury of the sciatic nerve in rats: a biochemical and stereological study.
Brain Res. 2009 Jan 9 ;1247:11-20. Epub 2008 Oct 21 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: