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Genome Biol. 2008 Oct 30;9(10):235. doi: 10.1186/gb-2008-9-10-235.

Large-scale assignment of orthology: back to phylogenetics?

Author information

  • Bioinformatics and Genomics Program, Center for Genomic Regulation, Doctor Aiguader 88, Barcelona, Spain. tgabaldon@crg.es

Abstract

Reliable orthology prediction is central to comparative genomics. Although orthology is defined by phylogenetic criteria, most automated prediction methods are based on pairwise sequence comparisons. Recently, automated phylogeny-based orthology prediction has emerged as a feasible alternative for genome-wide studies.

PMID:
18983710
[PubMed - indexed for MEDLINE]
PMCID:
PMC2760865
Free PMC Article

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