Arch Neurol. 1991 Aug;48(8):796-9.

Altered serotonergic and cholinergic synaptic markers in Pick's disease.

Source

Alzheimer's Disease Research Center/Sanders-Brown Center on Aging, Department of Pathology, University of Kentucky Medical Center, Lexington 40536-0230.

Abstract

Choline acetyltransferase and acetylcholinesterase activities as well as serotonin and imipramine binding were determined in the hypothalamus, nucleus basalis of Meynert, and frontal and temporal poles of subjects with Pick's disease. Choline acetyltransferase activity was decreased in the hypothalamus and nucleus basalis of Meynert, and acetylcholinesterase activity was decreased in the nucleus basalis of Meynert only. Serotonin binding was decreased in all sites but the nucleus basalis of Meynert, and imipramine binding was altered only in the frontal pole. Comparison with previous reports of Alzheimer's disease indicates that with respect to these synaptic markers, Alzheimer's disease and Pick's disease are not similar.

PMID:: 1898253; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Dementia - MedlinePlus Health Information

Molecular Biology Databases

IMIPRAMINE - HSDB

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

Neurochemical and histopathologic alterations characteristic of Pick's disease in a non-demented individual. [J Neuropathol Exp Neurol. 1994]
Neurochemical and histopathologic alterations characteristic of Pick's disease in a non-demented individual.
Sparks DL, Danner FW, Davis DG, Hackney C, Landers T, Coyne CM. J Neuropathol Exp Neurol. 1994 Jan; 53(1):37-42.
Monoaminergic and cholinergic synaptic markers in the nucleus basalis of Meynert (nbM): normal age-related changes and the effect of heart disease and Alzheimer's disease. [Ann Neurol. 1992]
Monoaminergic and cholinergic synaptic markers in the nucleus basalis of Meynert (nbM): normal age-related changes and the effect of heart disease and Alzheimer's disease.
Sparks DL, Hunsaker JC 3rd, Slevin JT, DeKosky ST, Kryscio RJ, Markesbery WR. Ann Neurol. 1992 Jun; 31(6):611-20.
A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease. [J Neurol Sci. 1983]
A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease.
Wood PL, Etienne P, Lal S, Nair NP, Finlayson MH, Gauthier S, Palo J, Haltia M, Paetau A, Bird ED. J Neurol Sci. 1983 Dec; 62(1-3):211-7.
Review Dysfunction of the brain cholinergic system during aging and after lesions of the nucleus basalis of Meynert. [J Neural Transm Suppl. 1994]
Review Dysfunction of the brain cholinergic system during aging and after lesions of the nucleus basalis of Meynert.
Pepeu G, Marconcini Pepeu I. J Neural Transm Suppl. 1994; 44:189-94.
Review The nucleus basalis of Meynert. [Can J Neurol Sci. 1986]
Review The nucleus basalis of Meynert.
Ezrin-Waters C, Resch L. Can J Neurol Sci. 1986 Feb; 13(1):8-14.

See reviews... See all...

Cited by 8 PubMed Central articles

Management of frontotemporal dementia: targeting symptom management in such a heterogeneous disease requires a wide range of therapeutic options. [Neurodegener Dis Manag. 2011]
Management of frontotemporal dementia: targeting symptom management in such a heterogeneous disease requires a wide range of therapeutic options.
Jicha GA, Nelson PT. Neurodegener Dis Manag. 2011 Apr; 1(2):141-156.
Review Abhorring the vacuum: use of Alzheimer’s disease medications in frontotemporal dementia. [Expert Rev Neurother. 2011]
Review Abhorring the vacuum: use of Alzheimer’s disease medications in frontotemporal dementia.
Kerchner GA, Tartaglia MC, Boxer A. Expert Rev Neurother. 2011 May; 11(5):709-17.
Eating and hypothalamus changes in behavioral-variant frontotemporal dementia. [Ann Neurol. 2011]
Eating and hypothalamus changes in behavioral-variant frontotemporal dementia.
Piguet O, Petersén A, Yin Ka Lam B, Gabery S, Murphy K, Hodges JR, Halliday GM. Ann Neurol. 2011 Feb; 69(2):312-9. Epub 2010 Nov 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Altered serotonergic and cholinergic synaptic markers in Pick's disease.
Altered serotonergic and cholinergic synaptic markers in Pick's disease.
Arch Neurol. 1991 Aug ;48(8):796-9.

PubMed
18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of gluc...
18F-FDG-PET of musculoskeletal tumors: a correlation with the expression of glucose transporter 1 and hexokinase II.
Ann Nucl Med. 2008 Oct ;22(8):699-705. Epub 2008 Nov 4 .

PubMed
Photoreceptor cell death mechanisms in inherited retinal degeneration.
Photoreceptor cell death mechanisms in inherited retinal degeneration.
Mol Neurobiol. 2008 Dec ;38(3):253-69. Epub 2008 Nov 4 .

PubMed
Is there an ideal stimulation regimen for IVF for poor responders and does it ch...
Is there an ideal stimulation regimen for IVF for poor responders and does it change with age?
J Assist Reprod Genet. 2008 Nov-Dec ;25(11-12):523-9. Epub 2008 Nov 4 .

PubMed
A longitudinal study on the role of spirituality in response to the diagnosis an...
A longitudinal study on the role of spirituality in response to the diagnosis and treatment of breast cancer.
J Behav Med. 2009 Apr ;32(2):174-86. Epub 2008 Nov 4 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Altered serotonergic and cholinergic synaptic markers in Pick's disease.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 8 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information