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    Autophagy. 2009 Jan;5(1):85-7. Epub 2009 Jan 13.

    Role of ULK-FIP200 complex in mammalian autophagy: FIP200, a counterpart of yeast Atg17?

    Hara T, Mizushima N.

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    Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan.

    Abstract

    The yeast serine threonine kinase Atg1 appears to be a key regulator of autophagy and its kinase activity is crucial for autophagy induction. Recent reports have indicated that a mammalian Atg1 homolog, UNC-51-like kinase (ULK) 1, is required for autophagy. We found that ULK1 localizes to the autophagic isolation membrane and its kinase activity is important for autophagy induction. Furthermore, we identified a focal adhesion kinase (FAK) family interacting protein of 200 kD (FIP200) as a ULK-interacting protein. FIP200 also localizes to the isolation membrane together with ULK. Using FIP200-deficient cells, we found that FIP200 is essential for autophagosome formation and the proper function of ULK. Here, we discuss the role of the ULK-FIP200 complex in autophagy and the possibility that FIP200 functions as a mammalian counterpart of Atg17.

    PMID:
    18981720
    [PubMed - indexed for MEDLINE]
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