Intern Med. 2008;47(21):1911-5. Epub 2008 Nov 4.

Hyperparathyroidism in a patient with autoimmune polyglandular syndrome.

Pelletier-Morel L, Fabien N, Mouhoub Y, Boitard C, Larger E.

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Hotel Dieu, APHP, Universite Rene Descartes, Paris, France.

Abstract

Autoimmune hypercalcemia has been reported in only a few cases, and never in the context of autoimmune polyglandular syndrome. A patient with type 1, insulin-dependent diabetes mellitus, Graves' disease, and antiparietal cell antibodies presented with persistent hypercalcemia with inappropriate PTH secretion. Other causes of hypercalcemia were excluded. In this context of two associated organ-specific autoimmune diseases we searched for autoantibodies directed to parathyroid tissue and to calcium-sensing receptor. Anti-parathyroid autoantibodies were detected by indirect immunofluorescence on parathyroid adenomas, and autoantibody against a peptide of the extracellular domain of the calcium-sensing receptor were detected by immunoblotting. Autoimmune hypercalcemia may be another organ-specific feature of autoimmune polyglandular syndrome.

PMID:: 18981636; [PubMed - indexed for MEDLINE]

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