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Cancer Cell. 2008 Nov 4;14(5):351-3. doi: 10.1016/j.ccr.2008.10.013.

Glycogen synthase kinase-3 and cancer: good cop, bad cop?

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  • 1Samuel Lunenfeld Research Institute, Toronto, ON, Canada.

Abstract

Dogma held that inhibition of the pleiotropic protein kinase glycogen synthase kinase-3 (GSK-3) was procarcinogenic due to its natural repression of beta-catenin. Now, Wang et al. have found the reverse in certain leukemias, possibly paving the way for small-molecule GSK-3 inhibitors as selective anticancer agents.

PMID:
18977324
[PubMed - indexed for MEDLINE]
PMCID:
PMC3006450
Free PMC Article
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