Am J Hum Genet. 1991 Oct;49(4):786-96.

Linkage analysis of quantitative traits: increased power by using selected samples.

Source

Institute for Behavioral Genetics, University of Colorado, Boulder 80309-0447.

Abstract

Although a number of methods have been developed for linkage analysis of quantitative traits, power is relatively poor unless there is a single major locus of very large effect. Here it is demonstrated that the use of selected samples (i.e., ascertainment of a proband with an extreme score on the quantitative measure) can dramatically increase power, especially when proband selection is performed on the tail of a distribution with an infrequent recessive gene. Depending on gene action and allele frequency, selected samples permit detection of a major locus that accounts for as little as 10%-20% of the phenotypic variation. The judicious use of selected samples can make an appreciable difference in the feasibility of linkage studies for quantitative traits.

PMID:: 1897525; [PubMed - indexed for MEDLINE]
PMCID:: PMC1683186

Free PMC Article

Publication Types, MeSH Terms, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Grant Support

DA05131/DA/NIDA NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

The power to detect linkage disequilibrium with quantitative traits in selected samples. [Am J Hum Genet. 2001]
The power to detect linkage disequilibrium with quantitative traits in selected samples.
Abecasis GR, Cookson WO, Cardon LR. Am J Hum Genet. 2001 Jun; 68(6):1463-74. Epub 2001 May 8.
Power and sample sizes for linkage with extreme sampling under an oligogenic model for quantitative traits. [Behav Genet. 2002]
Power and sample sizes for linkage with extreme sampling under an oligogenic model for quantitative traits.
Heo M, Faith MS, Allison DB. Behav Genet. 2002 Jan; 32(1):23-36.
New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling. [Genet Epidemiol. 2005]
New joint covariance- and marginal-based tests for association and linkage for quantitative traits for random and non-random sampling.
Tiwari HK, Holt J, George V, Beasley TM, Amos CI, Allison DB. Genet Epidemiol. 2005 Jan; 28(1):48-57.
Review Genetic linkage methods for quantitative traits. [Stat Methods Med Res. 2001]
Review Genetic linkage methods for quantitative traits.
Amos CI, de Andrade M. Stat Methods Med Res. 2001 Feb; 10(1):3-25.
Review Novel linkage mapping approach using DNA pooling in human and animal genetics. II. Detection of quantitative traits loci in dairy cattle. [J Appl Genet. 2002]
Review Novel linkage mapping approach using DNA pooling in human and animal genetics. II. Detection of quantitative traits loci in dairy cattle.
Pareek CS, Pareek RS, Walawski K. J Appl Genet. 2002; 43(3):309-18.

See reviews... See all...

Cited by 25 PubMed Central articles

Extremes of unexplained variation as a phenotype: an efficient approach for genome-wide association studies of cardiovascular disease. [Circ Cardiovasc Genet. 2010]
Extremes of unexplained variation as a phenotype: an efficient approach for genome-wide association studies of cardiovascular disease.
Lanktree MB, Hegele RA, Schork NJ, Spence JD. Circ Cardiovasc Genet. 2010 Apr; 3(2):215-21.
Review Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. [Schizophr Bull. 2007]
Review Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder.
Braff DL, Freedman R, Schork NJ, Gottesman II. Schizophr Bull. 2007 Jan; 33(1):21-32. Epub 2006 Nov 6.
The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration. [Schizophr Bull. 2007]
The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaboration.
Calkins ME, Dobie DJ, Cadenhead KS, Olincy A, Freedman R, Green MF, Greenwood TA, Gur RE, Gur RC, Light GA, et al. Schizophr Bull. 2007 Jan; 33(1):33-48. Epub 2006 Oct 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Linkage analysis of quantitative traits: increased power by using selected sampl...
Linkage analysis of quantitative traits: increased power by using selected samples.
Am J Hum Genet. 1991 Oct ;49(4):786-96.

PubMed
[ARX--one gene--many phenotypes].
[ARX--one gene--many phenotypes].
Neurol Neurochir Pol. 2008 Jul-Aug ;42(4):338-44.

PubMed
Localization of one gene for tuberous sclerosis within 9q32-9q34, and further ev...
Localization of one gene for tuberous sclerosis within 9q32-9q34, and further evidence for heterogeneity.
Am J Hum Genet. 1991 Oct ;49(4):764-72.

PubMed
Avoiding shame: young LGBT people, homophobia and self-destructive behaviours.
Avoiding shame: young LGBT people, homophobia and self-destructive behaviours.
Cult Health Sex. 2008 Nov ;10(8):815-29.

PubMed
DNA typing and genetic mapping with trimeric and tetrameric tandem repeats.
DNA typing and genetic mapping with trimeric and tetrameric tandem repeats.
Am J Hum Genet. 1991 Oct ;49(4):746-56.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: