Agents Actions. 1991 May;33(1-2):104-7.

Neurofibrillary tangles and histamine-containing neurons in Alzheimer hypothalamus.

Airaksinen MS, Reinikainen K, Riekkinen P, Panula P.

Source

Department of Anatomy, University of Helsinki, Finland.

Abstract

The location of histamine-immunoreactive (IR) cell bodies in normal aged human brain and in cases of Alzheimer's disease (AD) were compared to the distribution of neurofibrillary tangles (NFT). Cryostat sections were fixed with carbodiimide and processed for histamine-immunohistochemistry using the PAP technique. NFT were visualized in the same sections using thioflavin. Histamine-IR cell bodies in human brain were concentrated in the tuberomammillary (TM) nucleus that embodied a major part of the hypothalamus. Although located in similar large profiles and mainly concentrated in the TM area, the numerous hypothalamic NFT in AD were seldom found within the histamine-IR neurons.

PMID:: 1897426; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Histamine

LinkOut - more resources

Medical

Alzheimer's Disease - MedlinePlus Health Information

Molecular Biology Databases

HISTAMINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Histamine neurons in human hypothalamus: anatomy in normal and Alzheimer diseased brains. [Neuroscience. 1991]
Histamine neurons in human hypothalamus: anatomy in normal and Alzheimer diseased brains.
Airaksinen MS, Paetau A, Paljärvi L, Reinikainen K, Riekkinen P, Suomalainen R, Panula P. Neuroscience. 1991; 44(2):465-81.
Loss of large neurons and occurrence of neurofibrillary tangles in the tuberomammillary nucleus of patients with Alzheimer's disease. [Neurosci Lett. 1993]
Loss of large neurons and occurrence of neurofibrillary tangles in the tuberomammillary nucleus of patients with Alzheimer's disease.
Nakamura S, Takemura M, Ohnishi K, Suenaga T, Nishimura M, Akiguchi I, Kimura J, Kimura T. Neurosci Lett. 1993 Mar 19; 151(2):196-9.
Alz-50 immunoreactivity in the hypothalamus of the normal and Alzheimer human and the rat. [J Comp Neurol. 1991]
Alz-50 immunoreactivity in the hypothalamus of the normal and Alzheimer human and the rat.
Byne W, Mattiace L, Kress Y, Davies P. J Comp Neurol. 1991 Apr 22; 306(4):602-12.
Review Functional neuroanatomy and neuropathology of the human hypothalamus. [Anat Embryol (Berl). 1993]
Review Functional neuroanatomy and neuropathology of the human hypothalamus.
Swaab DF, Hofman MA, Lucassen PJ, Purba JS, Raadsheer FC, Van de Nes JA. Anat Embryol (Berl). 1993 Apr; 187(4):317-30.
Review Galanin tuberomammillary neurons in the hypothalamus in Alzheimer's and Parkinson's diseases. [Prog Brain Res. 1992]
Review Galanin tuberomammillary neurons in the hypothalamus in Alzheimer's and Parkinson's diseases.
Chan-Palay VL, Jentsch B. Prog Brain Res. 1992; 93:263-70.

See reviews... See all...

Cited by 1 PubMed Central article

Review Mouse behavioural analysis in systems biology. [Biochem J. 2005]
Review Mouse behavioural analysis in systems biology.
Van Meer P, Raber J. Biochem J. 2005 Aug 1; 389(Pt 3):593-610.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Neurofibrillary tangles and histamine-containing neurons in Alzheimer hypothalam...
Neurofibrillary tangles and histamine-containing neurons in Alzheimer hypothalamus.
Agents Actions. 1991 May ;33(1-2):104-7.

PubMed
Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation ...
Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation for an old problem.
JPEN J Parenter Enteral Nutr. 2008 Nov-Dec ;32(6):651-5.

PubMed
Pax8 protein stability is controlled by sumoylation.
Pax8 protein stability is controlled by sumoylation.
J Mol Endocrinol. 2009 Jan ;42(1):35-46. Epub 2008 Oct 30 .

PubMed
dictyBase--a Dictyostelium bioinformatics resource update.
dictyBase--a Dictyostelium bioinformatics resource update.
Nucleic Acids Res. 2009 Jan ;37(Database issue):D515-9. Epub 2008 Oct 30 .

PubMed
Moderate expression of prostate-specific membrane antigen, a tissue differentiat...
Moderate expression of prostate-specific membrane antigen, a tissue differentiation antigen and folate hydrolase, facilitates prostate carcinogenesis.
Cancer Res. 2008 Nov 1 ;68(21):9070-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: