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JPEN J Parenter Enteral Nutr. 2008 Nov-Dec;32(6):656-9. doi: 10.1177/0148607108324585.

Inflammation: roles in aging and sarcopenia.

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  • 1Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

Abstract

Aging is associated with inflammatory chronic conditions such as obesity, cardiovascular disease, insulin resistance, and arthritis. Sarcopenia-muscle loss with aging-is multifactorial with contributing factors that may include loss of alpha-motor neuron input, changes in anabolic hormones, decreased intake of dietary protein, and decline in physical activity. Research findings suggest that sarcopenia is a smoldering inflammatory state driven by cytokines and oxidative stress. Elevated levels of interleukin-6 and C-reactive protein are often detected. Sarcopenic obesity manifests the added inflammatory burden of adiposity and associated adipokines. Potential interventions for sarcopenia include nutritional supplements, physical activity/resistance exercise, caloric restriction, anabolic hormones, anti-inflammatory agents, and antioxidants. A key question is whether sarcopenia is truly a distinct syndrome or a milder form of a cachexia continuum.

PMID:
18974248
[PubMed - indexed for MEDLINE]
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