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Environ Microbiol. 2008 Nov;10(11):3026-35. doi: 10.1111/j.1462-2920.2008.01766.x.

Ammonia-dependent differential regulation of the gene cluster that encodes ammonia monooxygenase in Nitrosococcus oceani ATCC 19707.

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  • 1Department of Biology, Evolutionary and Genomic Microbiology Laboratory, University fo Louisville, Louisville, KY, USA.


Molecular analysis of the ammonia monooxygenase-encoding gene cluster in Nitrosococcus oceani revealed that the amo genes are differentially expressed from three promoters dependent on the external ammonia concentration. Whereas a distal amoRCABD operon promoter, pC1, is active only in the presence of ammonia, identified proximal amoC (pC2) and amoA (pA) sigma-70-type promoters are constitutive. Promoter region pC2 also contains a consensus sequence for binding of RpoN, usually involved in nitrogen starvation response. Additional regulation of transcript stability by anti-termination and mRNA degradation are proposed and discussed.

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