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FEBS J. 2008 Nov;275(22):5512-26. doi: 10.1111/j.1742-4658.2008.06696.x.

Natural polyphenols as proteasome modulators and their role as anti-cancer compounds.

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  • 1Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy.


The purpose of this review is to discuss the effect of natural antioxidant compounds as modulators of the 20S proteasome, a multi-enzymatic multi-catalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell-cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.

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