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Opt Express. 2008 Oct 27;16(22):18551-6.

Realtime photoacoustic microscopy of murine cardiovascular dynamics.

Author information

  • 1Department of Biomedical Engineering, Washington University, Optical Imaging Laboratory, St Louis, MO 63130, USA. zemp@ece.ualberta.ca

Abstract

Non-invasive visualization of cardiovascular dynamics in small animals is challenging due to their rapid heart-rates. We present a realtime photoacoustic imaging system consisting of a 30-MHz ultrasound array transducer, receive electronics, a high-repetition-rate laser, and a multicore-computer, and demonstrate its ability to image optically-absorbing structures of the beating hearts of young athymic nude mice at rates of approximately 50 frames per second with 100 microm x 25 microm spatial resolution. To our knowledge this is the first report of realtime photoacoustic imaging of physiological dynamics.

PMID:
18958134
PMCID:
PMC2644743
[PubMed - indexed for MEDLINE]
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