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Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK. paul.klenerman@ndm.ox.ac.uk
The CD8(+) T cell responses to CMV gradually increase in magnitude over time-so-called memory "inflation." In this issue of Immunity, Snyder et al. (2008) examine the dynamics of memory inflation and demonstrate continuous turnover of inflating T cells, drawing on both memory cells and naive cells to replace them.
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