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Curr Biol. 2008 Oct 14;18(19):R910-2. doi: 10.1016/j.cub.2008.07.082.

Signal transduction: turning a switch into a rheostat.

Author information

  • Department of Developmental and Cell Biology, University of California, Irvine, California 92697, USA. bardwell@uci.edu

Abstract

MAP kinase cascades are inherently switch-like, but, during yeast mating, MAPK signaling is graded. A new study suggests that the Ste5 scaffold protein is responsible for making this switch less switch-like.

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PMID:
18957235
[PubMed - indexed for MEDLINE]
PMCID:
PMC3017499
Free PMC Article

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