Int J Dev Biol. 2008;52(8):1099-103.

Dicer inactivation causes heterochronic retinogenesis in Xenopus laevis.

Decembrini S, Andreazzoli M, Barsacchi G, Cremisi F.

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Department of Biology, University of Pisa, Italy.

Abstract

Maturation of miRNAs by dicer is required in vertebrates for normal neural development. Here we report that dicer inactivation in Xenopus affects cell cycle progression, survival and timing of the generation of retinal cells, resulting in small retinas with lamination defects. In particular, dicer inactivation delays the exit from the cell cycle and the translation of key genes of late neurogenesis, highlighting a crucial role of miRNAs in retinal development.

PMID:: 18956342; [PubMed - indexed for MEDLINE]

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Dicer inactivation causes heterochronic retinogenesis in Xenopus laevis.

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