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J Lipid Res. 2009 Apr;50 Suppl:S145-9. doi: 10.1194/jlr.R800036-JLR200. Epub 2008 Oct 27.

The role of dysfunctional HDL in atherosclerosis.

Author information

  • 1Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA. mnavab@mednet.ucla.edu

Abstract

This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.

PMID:
18955731
[PubMed - indexed for MEDLINE]
PMCID:
PMC2674720
Free PMC Article
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