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Nat Struct Mol Biol. 2008 Nov;15(11):1221-2. doi: 10.1038/nsmb.1509. Epub 2008 Oct 26.

Structural basis for exon recognition by a group II intron.

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  • 1Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA.

Abstract

Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-A crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.

PMID:
18953333
[PubMed - indexed for MEDLINE]
PMCID:
PMC2735234
Free PMC Article
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