Monoterpenic fragment analogues of aplasmomycin as potential antimalarial

N Balu; J V Thomas; S V Bhat

doi:10.1021/jm00113a021

Monoterpenic fragment analogues of aplasmomycin as potential antimalarial

J Med Chem. 1991 Sep;34(9):2821-3. doi: 10.1021/jm00113a021.

Authors

N Balu¹, J V Thomas, S V Bhat

Affiliation

¹ Department of Chemistry, Indian Institute of Technology, Powai, Bombay.

PMID: 1895301
DOI: 10.1021/jm00113a021

Abstract

Seven analogues of monoterpenic fragment of aplasmomycin were synthesized as targeted antimalarial agents. The potency of the compound 6 was comparable with the sesquiterpene lactone artemisinin and the antibiotic aplasmomycin in vivo against Plasmodium berghei yoelli.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents*
Antimalarials*
Ionophores
Male
Mice
Peptides / chemistry
Peptides / pharmacology
Plasmodium berghei / drug effects
Terpenes / chemistry*

Substances

Anti-Bacterial Agents
Antimalarials
Ionophores
Peptides
Terpenes
aplasmomycin