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Ann Rheum Dis. 2009 Mar;68(3):416-9. doi: 10.1136/ard.2008.095414. Epub 2008 Oct 24.

Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis.

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  • 1Division of Rheumatology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy.

Abstract

OBJECTIVE:

To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome.

METHODS:

Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 with longstanding RA (LSRA)) and from 248 gender-matched controls from the same geographical area. Clinical and immunological characteristics were recorded for all the patients.

RESULTS:

The percentage of the 2/2 genotype was higher in patients with ERA (27.0%), and in patients with LSRA (34.2%), than in controls (14.9%) (ERA: OR = 2.11 (95% CI 1.20 to 3.70) vs controls; LSRA: OR = 2.96 (95% CI 1.76 to 5.00) vs controls). A lower representation of allele *3 was present in patients with ERA (2.0%) than in controls (6.0%; OR = 0.32 (95% CI 0.11 to 0.91)). No significant associations were found between polymorphisms and autoantibodies positivity.

CONCLUSION:

The HS1,2A allele *2 associates with early and longstanding RA.

PMID:
18952640
[PubMed - indexed for MEDLINE]
PMCID:
PMC2633630
Free PMC Article

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