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Klin Padiatr. 2008 Nov-Dec;220(6):388-90. doi: 10.1055/s-0028-1086022. Epub 2008 Oct 23.

Hodgkin lymphoma as second malignancy during continuing chemotherapy for childhood acute lymphoblastic leukemia.

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  • 1Department of Pediatric Hematology and Oncology, Shohada Medical Center, Shaheed Beheshti University of Medical Sciences, Tehran-Tajrish, Iran.


Acute lymphoblastic leukemia (ALL) is the most prevalent childhood malignancy in most parts of the world with a 5-year survival rate above 70%. Long-term survivors are at risk for treatment-related late effects and second malignant neoplasms (SMNs). SMNs occur with a mean latency of 6-6.7 years after ALL diagnosis but are rarely observed during maintenance chemotherapy (CT). Hodgkin lymphoma (HL) as a complication of ALL is very rare. We report two children with ALL who developed HL while receiving maintenance CT. Both received appropriate chemo- and radiotherapy (CT/RT) and have survived for more than10 years.

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