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Rev Med Chil. 2008 Jul;136(7):900-4. doi: /S0034-98872008000700013. Epub 2008 Sep 4.

[McKittrick- Wheelock syndrome: report of one case].

[Article in Spanish]

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  • 1Clínica Médica 2, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.


Villous colorectal adenomas are common tumors that normally provoke scarce symptomatology. We report a 59 year-old female that was admitted with severe dehydration due to severe diarrhea lasting 10 days and vomiting in the last 48 hours. On rectal palpation a large tumor located 5 cm above the anus was palpated. Colonoscopy confirmed the presence of a villous adenoma that was excised surgically. In this patient, the fluid and electrolyte hypersecretion of the rectal villous adenoma provoked a depletion syndrome with serious hydroelectrolytic alterations, acute renal failure and hypovolemic shock. This syndrome was first described by McKittrick and Wheelock in 1954.

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