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Hastings Cent Rep. 2008 Sep-Oct;38(5):39-48.

Comparing drug effectiveness at health plans: the ethics of cluster randomized trials.

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  • 1Harvard Medical School, USA.


"Cluster randomized trials," in which groups of patients are randomly assigned to different therapeutic interventions, provide a powerful way of evaluating drugs. CRTs have not been widely used, in good part because of concerns about whether patients must give informed consent to participate in them. A better understanding of how CRTs fit into clinical practice resolves the concerns.

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