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    Hastings Cent Rep. 2008 Sep-Oct;38(5):39-48.

    Comparing drug effectiveness at health plans: the ethics of cluster randomized trials.

    Sabin JE, Mazor K, Meterko V, Goff SL, Platt R.

    Source

    Harvard Medical School, USA.

    Abstract

    "Cluster randomized trials," in which groups of patients are randomly assigned to different therapeutic interventions, provide a powerful way of evaluating drugs. CRTs have not been widely used, in good part because of concerns about whether patients must give informed consent to participate in them. A better understanding of how CRTs fit into clinical practice resolves the concerns.

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    PMID:
    18947140
    [PubMed - indexed for MEDLINE]

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