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Nat Rev Mol Cell Biol. 2008 Nov;9(11):833-45. doi: 10.1038/nrm2525.

Coordinated protein sorting, targeting and distribution in polarized cells.

Author information

  • 1Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA. mellman.ira@gene.com

Abstract

The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell-cell and cell-substrate adhesion orientate the three-dimensional distribution of intracellular signalling complexes and, accordingly, the direction of membrane traffic. The integration of these mechanisms into a complex and dynamic network is crucial for normal tissue function and is often defective in disease states.

PMID:
18946473
[PubMed - indexed for MEDLINE]
PMCID:
PMC3369829
Free PMC Article

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