ABSTRACT: BACKGROUND: Infective Endocarditis is associated with a high incidence of embolic events, commonly involving the central nervous system, spleen, kidney, lungs, heart and eyes. CASE PRESENTATION: We report a case of infective endocarditis with late embolization to the L5/S1 region of the spine leading to spondylo-discitis. The disc space infection presented ten days after completion of antibiotic therapy based on blood culture and antibiotic sensitivity. CONCLUSION: This is the first reported case of acute infective spondylo-discitis demonstrated on MR imaging following completion of appropriate antibiotic therapy.