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Med J Malaysia. 2008 Jun;63(2):150-1.

Small cell variant of anaplastic large cell lymphoma with positive immunoreactivity for CD99.

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  • 1Department of Pathology, Universiti Putra Malaysia, Serdang, Malaysia. mshiran@yahoo.com

Abstract

A 13 year old boy presented with a huge mass on his right arm of 6 months duration. Histopathological examination revealed sheets of malignant small round blue cells with immunopositivity for LCA, CD43, CD45Ro, CD30, EMA, ALK-1 and CD99, and negativity for CD20, TdT, myogenin, myoD1, NSE, bcl-6, bcl-2 and CD10. Fluorescent In-Situ Hybridization (FISH) testing excluded the diagnosis of Ewing's sarcoma/PNET. Pathologists need to be aware of the diagnosis of a small cell variant of ALCL, as well as of the fact that CD99 expression commonly occurs in cases of ALK-positive ALCL, in order to distinguish this entity from Ewing's sarcoma/PNET.

PMID:
18942305
[PubMed - indexed for MEDLINE]
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