Complete genomic sequence of the goat prion protein gene (PRNP)

Virus Genes. 2009 Feb;38(1):189-92. doi: 10.1007/s11262-008-0288-z. Epub 2008 Oct 22.

Abstract

Prion protein genetics plays a central role in transmissible spongiform encephalopathies, a disease occurring in human and animals. Here we report a 27-kb genomic sequence containing the goat PRNP gene. It shows, both in structure and content, a remarkable similarity with its sheep ortholog and can serve as a basis for future (comparative) studies with reference to the regulation of PRNP gene expression and the search for genetic tools to prevent/control/eradicate (goat) TSE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Goats
  • Molecular Sequence Data
  • Prions / genetics*
  • Sequence Analysis, DNA

Substances

  • Prions

Associated data

  • GENBANK/EU870890