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Mol Vis. 2008;14:1845-9. Epub 2008 Oct 12.

Interleukin-1 gene polymorphisms and toxoplasmic retinochoroiditis.

Author information

  • 1Uveitis Section, Department of Ophthalmology, School of Medicine, Belo Horizonte, Brazil. cordeiro.cy@gmail.com

Abstract

PURPOSE:

It has been proposed that cytokine gene polymorphisms can predispose individuals to disease by enhancing inflammatory processes. Considering the relevance of interleukin-1 (IL-1) in the pathogenesis of toxoplasmic retinochoroiditis (TR), we investigated whether IL1A -889 C/T and IL1B +3954C/T promoter polymorphisms are associated with TR in humans.

METHODS:

We performed a cross-sectional study that involved 100 Brazilian TR patients and 100 age- and gender-matched control subjects. Genomic DNA was obtained from oral swabs of all participants and amplified using polymerase chain reaction (PCR) with specific primers flanking the locus -889 of IL1A and +3954 of IL1B. PCR products were submitted to digestion and analyzed by PAGE to distinguish C and T alleles.

RESULTS:

There was no significant difference in the genotype or allele distributions of the IL1A -889 C/T and IL1B +3954C/T polymorphisms in patients with TR when compared with controls. However, in a subgroup analysis, the frequency of genotype and allele distributions of IL1A -889 C/T differed significantly between TR patients with and without recurrent episodes.

CONCLUSION:

This study suggests that the genotypes related with a high production of IL-1a may be associated with the recurrence of TR.

PMID:
18941541
[PubMed - indexed for MEDLINE]
PMCID:
PMC2568892
Free PMC Article
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