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AJR Am J Roentgenol. 2008 Nov;191(5):1570-5. doi: 10.2214/AJR.07.3482.

Chest radiographic and CT manifestations of chronic granulomatous disease in adults.

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  • 1Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada. migbarco@gmail.com

Abstract

OBJECTIVE:

The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults.

MATERIALS AND METHODS:

We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection.

RESULTS:

Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation.

CONCLUSION:

The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.

PMID:
18941103
[PubMed - indexed for MEDLINE]
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