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Clin Experiment Ophthalmol. 2008 Jul;36(5):422-5.

Ocular surface squamous neoplasia as the first apparent manifestation of HIV infection in Malawi.

Author information

  • 1Lion's Sight First Eye Hospital, College of Medicine, Blantyre, Malawi. martin.spitzer@med.uni-tuebingen.de

Abstract

PURPOSE:

To evaluate the prevalence of undiagnosed and asymptomatic HIV infection in patients with ocular surface squamous neoplasia (OSSN) in an urban patient population in Malawi.

METHODS:

A consecutive series of patients presenting with OSSN was evaluated in an African academic centre. A detailed history and physical examination in 53 consecutive patients with conjunctival squamous cell carcinoma and conjunctival intraepithelial neoplasia were performed. Thirty eight (72%) patients agreed to undergo serological HIV testing.

RESULTS:

Seventy-nine per cent (30 of 38) patients were HIV positive. None of the patients had previous HIV testing or was aware of having symptoms of HIV. Seventy per cent (n = 21) of the HIV-positive patients had no other symptoms suggestive of HIV infection or any other disease. Patients were far more likely to refuse HIV testing if they were married and male.

CONCLUSIONS:

The conjunctival tumour may be the primary and only apparent manifestation of HIV in patients presenting with OSSN in Sub-Saharan Africa.

PMID:
18939345
[PubMed - indexed for MEDLINE]
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